In 2K22, those defenders don't seem to 2K22 MT crash as much and you can play a games that feel more like an NBA game. Now, it's all about understanding the defense and making the right decisions. If you ask your center to set a pick and the player you're calling for decides to go to you, you can throw it over to the big guy and let him play the smaller player. If they don't switch congratulations on your new lanes. Make it to the bucket, and score a layup or get fouled.
To begin a pick-and roll, press and hold L1 (LB on Xbox) while pointing to the player you'd like to select. The key is to take your time. If you don't get the switch and don't see the lane, don't push it. Reset the switch and try again. Remember, you want to play smart and slow.
The same applies to players who want to really delve in NBA 2K22 for the first time this season. Whether you want to play MyTeam, MyCareer, or MyWNBA you'll likely need make a decision and stick to it. That doesn't mean you can't play around with other options, but all three of them come with a season's pass that includes content that you can unlock. It's a little easier to complete the pass than this year, however If you're spreading yourself too thinly, you may not be able to collect all the rewards.
But if you're an amateur player don't worry about it. There's plenty of options and moving between them isn't too difficult unless really want to compete with other players.
If you're already a top-end MyTeam participant, then this article won't work for you. You're likely to have the stick skills to 2K22 mt buy compete in online. However, for players who aren't as experienced (or players who need a refresh) playing offline games like Triple Threat Offline and Domination can do two very beneficial things.